Progesterone: What It Does, How It's Used, and What You Need to Know

When your body needs to prepare for pregnancy or manage menopause, progesterone, a natural hormone produced by the ovaries that regulates the menstrual cycle and supports early pregnancy. Also known as the pregnancy hormone, it works alongside estrogen to keep your reproductive system running smoothly. Without enough progesterone, you might have irregular periods, trouble getting pregnant, or worse menopause symptoms like hot flashes and sleep problems.

Progesterone isn’t just for women trying to conceive. It’s also used in hormone therapy, a treatment that replaces or balances hormones lost during menopause to reduce hot flashes and protect the uterus from overgrowth when estrogen is taken alone. For some, it’s part of fertility treatment, a medical approach to help women ovulate or maintain early pregnancy. And yes, low progesterone can mess with your mood, energy, and even your skin—something many women notice long before their doctor does.

What you won’t find in a simple blood test is how your body actually uses progesterone. Two women with the same level can feel totally different because of how their cells respond. That’s why some people need creams, others take pills, and some get shots. It’s not one-size-fits-all. And while many turn to hormonal balance, the state where estrogen, progesterone, and other hormones work together without excess or deficiency through supplements or herbs, not all of them actually raise progesterone the way your body needs it to.

You’ll find posts here that compare progesterone to other treatments for menopause, explain why it’s used in IVF, and even warn about what happens when you stop it cold turkey. Some people swear by natural methods. Others need prescriptions to feel normal again. We’ve gathered real experiences—what worked, what didn’t, and what your doctor might not tell you. Whether you’re dealing with irregular cycles, trying to get pregnant, or just tired of night sweats, the info below is meant to help you make smarter choices—without the hype.

Compare Prometrium (Progesterone) with Alternatives: What Works Best for You

Compare Prometrium (Progesterone) with Alternatives: What Works Best for You

Compare Prometrium with generic progesterone, vaginal gels, injections, and creams to find the most effective, affordable, and safe alternative for your needs - whether for fertility, menopause, or menstrual health.